By Jacob Williamson-Rea jacobw2 through cmu. Chris Bettinger , an associate professor of materials science and engineering and biomedical engineering at Carnegie Mellon University, is working to improve aneurysm treatments through a partnership with Ancure, LLC, a Pittsburgh-based company that specializes in medical device coatings, as well as Michael Horowitz, a neurosurgeon at the Pennsylvania Brain and Spine Institute. An aneurysm occurs when the weakened vessels lead to a bulge in vasculature, causing blood to pool in the bulge.
Ruptured aneurysms can occur at any age, and the mortality rate is almost 60 percent without treatment. Current treatments involve endovascular therapy, which is administered through a catheter. Surgeons insert a platinum coil through the catheter and directly into the defect, causing a blood clot and ultimately sealing off the vasculature defect. Unfortunately, treatment fails 30 percent of the time because the body breaks down and absorbs the tissue clot, and the aneurysm forms again.
Surgeons have to perform the same procedure, and patients face a 30 percent failure rate each time. This model isn't sustainable, so Bettinger, Horowitz and Ancure aim to make aneurysm treatments more permanent. Through a grant from the Pennsylvania Infrastructure Technology Alliance , the team has been testing GeniCoat, a genipin-based, controlled release material. Genipin is a chemical compound derived from gardenia fruit extract that serves as an extremely successful cross-linker for proteins.
In a paper appearing in the Dec. Pigment-based anodes are an important component in sodium-ion batteries, a battery technology that has been pioneered by Whitacre, an associate professor of materials science and engineering and engineering and public policy.
At present, high-performance energy storage systems for medical devices are designed to supply power to semi-permanent devices that are often encapsulated. These scenarios permit the use of potentially toxic electrode materials and electrolytes. Electronically active medical devices that are either biodegradable or ingestible require new energy storage materials that are benign and can operate in hydrated environments.
Melanin-based electrodes represent a step closer to this goal. Earlier this year, Bettinger and Whitacre reported that they were creating edible power sources for medical devices using materials found in a daily diet.
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Earlier this year, Bettinger and Whitacre reported that they were creating edible power sources for medical devices using materials found in a daily diet. Their initial design involved a flexible polymer electrode and a sodium ion electrochemical cell, which allows them to fold the mechanism into an edible pill that temporarily encapsulates the device. Bettinger has worked for more than a decade at the interface of materials science and biomedical engineering.
Some of his innovative technologies include new synthetic materials that mimic the natural properties of soft tissue and biodegradable electronics that could usher in a new era of electronically active implants. Whitacre studies the materials science of synthesizing and implementing promising materials and device architectures for energy storage and generation technologies.
Ink from the cuttlefish pictured above , a close relative of the squid, provides the perfect chemistry and nanostructure to power tiny electronic devices that can be either ingested or implanted into the body for applications ranging from biosensing to drug delivery. Official Events Calendar. The Digest-O-Mat converts organics waste into cooking gas and fertilizer for restaurants and commercial food kitchens.
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